Within our brains the basal ganglia is one of the body's motion control centre. Inside the basal ganglia is a region called the striatum which allows us to direct our body's movements to accomplish what we want to do. Below the striatum is an area called the substantia nigra. This area is rich in cells that produce a chemical called dopamine, these dopamine producing cells have long wire like projections that connect them to the striatum. When the substantia nigra sends a signal these cells release dopamine into the striatum. Inside the striatum dopamine helps the striatal cells receive the brains motion control messages.
In the healthy brain plenty of dopamine is available to help these brain cells do their job. In Parkinson's disease the dopamine producing nerve cells in the substantia nigra die. As a result the long wire like projections of these cells disappear unless dopamine is provided to the striatum to help movement messages get through. This leads to the cardinal features of Parkinson's disease, for example slowness of movement, tremor and rigidity.
(7)
Parkinson's disease is a degenerative disease, which means that these symptoms will get worse overtime as more dopamine cells are lost. PD. also causes symptoms that aren't movement related, including:
- Problems with gait and balance
- Cognitive dysfunction
- Depression
- Constipation
Scientists are not sure what causes these symptoms and no treatments effectively address them. Research is on going to better understand these symptoms as well as the dopamine degeneration seen in PD. This will help us develop treatment to improve patients quality of life.(5)
Great research so far Yasemin, don't forget to refer to chapter 6 of the extended project text when you are planning how to structure your work.
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ReplyDeleteMy husband was diagnosed of Parkinsons disease 2 years ago, when he was 49. He had a stooped posture, tremors, right arm does not move and also a pulsating feeling in his body. He was placed on Senemet for 8 months and then Siferol was introduced and replaced the Senemet, during this time span he was also diagnosed with dementia. He started having hallucinations, lost touch with reality. Suspecting it was the medication I took him off the Siferol (with the doctor’s knowledge) and started him on PD natural herbal formula we ordered from Health Care HERBAL CENTRE, his symptoms totally declined over a 3 weeks use of the Health Care HERBAL Parkinsons disease natural herbal formula. He is now almost 51 and doing very well, the disease is totally reversed! Visit w w w. healthcareherbalcentre .com
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